How optimization of potential functions affects protein folding.

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چکیده

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How optimization of potential functions affects protein folding.

The relationship between the optimization of the potential function and the foldability of theoretical protein models is studied based on investigations of a 27-mer cubic-lattice protein model and a more realistic lattice model for the protein crambin. In both the simple and the more complicated systems, optimization of the energy parameters achieves significant improvements in the statistical-...

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To my mentors iii ACKNOWLEDGEMENTS First, I would like to express my sincere appreciation to my advisor, Dr. Joel Sokol for his invaluable guidance, support, inspiration, understanding, and friendship throughout the entire period of my research. Dr. Emilie Danna for their willingness to serve on my dissertation committee and for their valuable comments and suggestions. I also thank Dr. Emilie D...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1996

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.93.10.4984